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When does animal research become unnecessary and cruel? A paper’s methods give a biologist pause

Microbiologist Elies Bik is well-known for applying a close eye to studies, and has spent years anonymously submitting reports on plagiarism and image duplication to journal editors.

No publication without confirmation

Jeffrey S. Mogil and Malcolm R. Macleod propose a new kind of paper that combines the flexibility of basic research with the rigour of clinical trials.

A new reproducibility fix? Get your work checked before it’s published

Most researchers by now recognize there’s a reproducibility crisis facing science. But what to do about it? Today in Nature, Jeffrey S. Mogil at McGill University and Malcolm R. Macleod at the University of Edinburgh propose a new approach: Restructure the reporting of preclinical research to include an extra “confirmatory study” performed by an independent lab, which verifies the findings before they are published. We spoke with them about how this could work.

Rigorous replication effort succeeds for just two of five cancer papers

The first results of a high-profile effort to replicate influential papers in cancer biology are roiling the biomedical community.

Cancer reproducibility project releases first results

An open-science effort to replicate dozens of cancer-biology studies is off to a confusing start.

The Researchers’ View of Scientific Rigor—Survey on the Conduct and Reporting of In Vivo Research

Reproducibility in animal research is alarmingly low, and a lack of scientific rigor has been proposed as a major cause.

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor

Accumulating evidence indicates high risk of bias in preclinical animal research, questioning the scientific validity and reproducibility of published research findings.